The application of AI in the medical field is a medical theme with great potential, but there are still few examples of its practical application. Based on 1) a perspective that emphasizes understanding of medical needs and development in the medical field, 2) a network with many physicians and departments, and 3) experience and know-how accumulated through investigator-initiated clinical trials, we are working as a hub that links physicians at medical institutions, IT vendors with AI technology, and pharmaceutical/health tech companies for industrialization. We are working to build an ecosystem that connects AI research to business in the medical field. Since we can conduct clinical trials in accordance with the Pharmaceutical Affairs Law, it will be possible for us to develop full-scale medical solutions (diagnosis and treatment) that can be used in actual clinical practice.
Although spirometry is the most important test for respiratory diseases and respiratory function, it is not widely used. This is because it is difficult for non-specialists to interpret the results (flow volume curve). In collaboration with Kyoto University and NEC Solution Innovator Ltd, we are developing an AI to diagnose respiratory functions and diseases from spirometry test results (flow volume curves). In July 2020, we signed a joint development and commercialization agreement (license agreement) with CHEST M.I. Inc., a leading company in spirometry. Since development of an initial AI model capable of differential diagnosis of various respiratory diseases has been successfully completed, we received a milestone in October 2021 based on the agreement with Chest M.I. Inc. We plan to improve the prediction accuracy by improving the number and quality of data in order to develop it for commercialization.
Hemodialysis is the major treatment for kidney failure. Normally, a dialysis hospital manages dozens of patients with one doctor and several nurses and clinical engineers, but the human resources are not sufficient, and the occurrence of complications such as hypotension during dialysis consumes scarce human resources and also adversely affects the life prognosis of patients. We are developing AI to predict hypotension events in advance with Tohoku University, University of Tokyo, St. Luke’s International University, several private medical institutions, and NEC Corporation (NEC). We are able to collect a large amount of high-quality medical data of dialysis from our medical network. In the future, we will further increase the amount of medical data (hundreds of thousands of dialysis treatments) and improve the prediction accuracy by upgrading the analysis engine to enable reinforcement learning for individual patients. We have concluded a collaboration agreement with Nipro Corporation, a global hemodialysis medical equipment supplier, in May 2021 with a view to industrialization. We will continue to improve the accuracy and functionality of the AI, by careful examining each clinical parameter carefully, improving the AI to learn from individual patients (personalized AI), and adding a function to predict safe dialysis water removal in addition to blood pressure drop during dialysis.
Insulin injection therapy is necessary for strict control of blood sugar levels in diabetes mellitus. Since the safety margin of insulin therapy is narrow and overdose can cause the serious side effect of hypoglycemia, the optimal type and dosage must be set for each patient. This requires the knowledge and experience of a specialist for diabetes, and it is difficult for a non-specialist to set the insulin dose. In collaboration with Tohoku University and NEC Corporation, we have developed an AI that can predict insulin dosage within an error of two units. We plan to conduct a multicenter clinical trial to verify the accuracy. In November 2021, we executed a joint research agreement with Nipro Corporation.
In today’s aging society, dysphagia is considered to be a major cause of pneumonia, but there is no simple method for assessment of swallowing function. The organs used for ‘speaking’ and ‘swallowing’ are largely common, and we have focused on the possibility of predicting the swallowing function from the evaluation of the speaking function. We are working on the development of an AI to evaluate the swallowing function by analyzing the difference in the pronunciation between healthy people and patients.
Developmental disabilities are important disorders that impair the social life of children, including autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), and learning disabilities. With early treatment and proper education, those with developmental disorders can lead to a social life similar to normal people. The prevalence of dyslexia, one of the learning disabilities, is as high as 2% in children, and as a result of the time consuming and burdensome process of reading aloud, it can lead to poor school performance and truancy. In collaboration with Tohoku University, Tohoku Medical Megabank Organization, Miyagi Children’s Hospital and NEC Corporation, we are developing a system to evaluate dyslexia using AI, based on data from children reading letters and sentences aloud. We have started to collect data from the developmental disability survey of 8-year-old children at the Tohoku Medical Megabank Organization, which started in October 2021.