Development status

Malignant melanoma



Melanoma is a malignant transformation of pigment-producing cells called melanocytes in the epidermis, and is considered to be a highly malignant form of skin cancer with a high metastatic rate.

 

PAI-1 inhibitor was shown to enhance the therapeutic effect of anti-PD-1 antibody on melanoma in a mouse tumor-bearing model transplanted with melanoma cell lines, indicating that PAI-1 inhibitor improves the immune environment in the tumor to facilitate the action of anti-PD-1 antibody.

 

An investigator-initiated clinical trial (Phase II study) is conducted to confirm the efficacy and safety of PAI-1 inhibitor in combination with nivolumab in collaboration with six universities that have established the Japan Skin Cancer Network (JSCaN), a non-profit organization, to improve treatment outcomes for melanoma.

RS5614によるPD-L1発言阻害